RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Ptgs2
RNA ID
RNA Type
mRNA
Alteration Pattern
histone hyperacetylation
Species
mus musculus
Detection Methods
qRT-PCR; Immunofluorescence etc.
Target
NA
Pathway
NA
PubMed ID
Title
Diallyl disulfide inhibits proliferation and transdifferentiation of lung fibroblasts through induction of cyclooxygenase and synthesis of prostaglandin E
Year
2014
Function
"In DADS-treatedlung fibroblasts, upregulated expression of COX-2 was a result of increased level of histone 3 acetylation at COX-2 locus, which lead to inhibition of proliferation and transdifferentiation of lung fibroblasts."